Past Events

#October

Monday, October 8, 2018 at 13:00
Medisiina D, Sakari Alhopuro Lecture hall, Kiinamyllynkatu, Turku

Welcome words by the Dean, coffee, cake and sparkling wine. Music by Aura Brass Band in Medisiina D lobby

Opening programme (in Finnish) on Monday, 8 October at 2pm in Sakari Alhopuro lecture hall in Medisiina D

KUN LÄÄKETIEDE KOHTASI POLITIIKAN – YHTEISKUNNALLISIA PAINEITA LÄÄKETIETEELLISEN TIEDEKUNNAN VAIHEISSA
Vesa Vares, Professor of Political History, UTU

LÄÄKETIETEELLISEN TIEDEKUNNAN TÄHTIHETKIÄ JA TAITEKOHTIA
Timo Niitemaa, M.Soc.Sci, Communications Officer (emeritus), UTU

TULEVAISUUDEN NÄKYMIÄ
Markku Wilenius, Professor of Futures Studies UTU

Welcome to join the festive activities!

Programme of the festival week

“Grand Opening of the 75th Anniversary Festival Week of the Faculty of Medicine”

Welcome words by the Dean, coffee, cake and sparkling wine. Music by Aura Brass Band in Medisiina D lobby

Opening programme (in Finnish) on Monday, 8 October at 2pm in Sakari Alhopuro lecture hall in Medisiina D

KUN LÄÄKETIEDE KOHTASI POLITIIKAN – YHTEISKUNNALLISIA PAINEITA LÄÄKETIETEELLISEN TIEDEKUNNAN VAIHEISSA
Vesa Vares, Professor of Political History, UTU

LÄÄKETIETEELLISEN TIEDEKUNNAN TÄHTIHETKIÄ JA TAITEKOHTIA
Timo Niitemaa, M.Soc.Sci, Communications Officer (emeritus), UTU

TULEVAISUUDEN NÄKYMIÄ
Markku Wilenius, Professor of Futures Studies UTU

Welcome to join the festive activities!

Programme of the festival week

Tuesday, October 2, 2018 at 15:00
T-Hospital, Haartman Lecture Hall, Savitehtaankatu 1, Turku

Eleonora Mäkelä: Novel diagnostic markers in AML

Mari Suominen: Radium-223 dichloride as a dual inhibitor of the vicious cycle and tumor growth in breast and prostate cancer bone metastasis models

“Cancer seminar: Eleonora Mäkelä and Mari Suominen”

Eleonora Mäkelä: Novel diagnostic markers in AML

Mari Suominen: Radium-223 dichloride as a dual inhibitor of the vicious cycle and tumor growth in breast and prostate cancer bone metastasis models

#September

Wednesday, September 12, 2018 at 14:00
Turku Centre for Biotechnology, 5th floor seminar room, BioCity B-staircase, Tykistökatu 6, Turku

Programme here

“Bioinformatics journal club”

Programme here

Tuesday, September 4, 2018 at 15:00
Medisiina D, Lauren 1 Lecture Hall, Kiinamyllynkatu, Turku

Dr. Hans Hendriks, Hendriks Pharmaceutical Consulting

Coffee served at 14:45

 

Hans Hendriks, Ph.D., held positions in Cell Biology and Immunology at the Vrije Universiteit (Amsterdam, The Netherlands). After 17 years he joined the New Drug Development Office (now part of INC Research), Europe’s foremost oncology Contract Research Organisation (Amsterdam, The Netherlands), gaining 12 years experience leading international drug discovery and development collaborations. In addition, he served in various drug development and drug evaluation committees of the EORTC, Cancer Research UK and US National Cancer Institute, and held for 8 years a position in the Executive Board of the EORTC Biological Therapeutics Development Group.

He established Hendriks Pharmaceutical Consulting January 2000, an independent consultancy company providing services to small companies and biotechs in Oncology R&D. He is co-founder of the Biotherapy Development Association (Germany, 2001) and served on the Scientific Advisory Board of a German biotech company (2001-2003). He was the National Network Representative for The Netherlands in the Council of the European Association for Cancer Research (EACR), period 2013-2018, and received a  honorary EACR membership as of 2018.

From 2002-2006 Dr. Hendriks acted as Project Technical Assistant to the European Commission (DG Research) in the 5th Framework Programme (FP) overseeing 20 cancer-related EU-funded projects, served as expert evaluator in 5th, 6th, 7th FP and H2020 of the EU and acted as Administrative Manager for the FP6 CompuVac project (June 2008-October 2009). In addition, he assisted Austrian, Dutch, Italian, and Slovenian consortia in the preparation and submission of grant applications for the European Union’s 7th FP, H2020 and the Innovative Medicines Initiative 2.

He was successful in bringing the telomere targeting agent KML001 from early stage preclinical research to Phase I clinical studies (CCR 2008;14:4593-602) and is co-inventor of a US patent application (2009).

Hendriks Pharmaceutical Consulting is member of the Competence Network Life Science (www.conelis.org), an association of selected life science experts that provides top-tier consulting services to the pharmaceutical industry. It is a network of highly qualified and independent experts who can be contracted individually or as part of an interdisciplinary team.

Selected publications

Hendriks. H. et al., Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative, British Journal of Cancer, 2017.

Peters, GJ., Govaerts, A-S., Hendriks, H. for the EORTC-pharmacology and molecular mechanism group. The role of pharmacology in anticancer drug development, ADMET, 2018

“Cancer Seminar Series: Pharmacology directed strategies in anticancer drug development, a viable approach for academia?”

Dr. Hans Hendriks, Hendriks Pharmaceutical Consulting

Coffee served at 14:45

 

Hans Hendriks, Ph.D., held positions in Cell Biology and Immunology at the Vrije Universiteit (Amsterdam, The Netherlands). After 17 years he joined the New Drug Development Office (now part of INC Research), Europe’s foremost oncology Contract Research Organisation (Amsterdam, The Netherlands), gaining 12 years experience leading international drug discovery and development collaborations. In addition, he served in various drug development and drug evaluation committees of the EORTC, Cancer Research UK and US National Cancer Institute, and held for 8 years a position in the Executive Board of the EORTC Biological Therapeutics Development Group.

He established Hendriks Pharmaceutical Consulting January 2000, an independent consultancy company providing services to small companies and biotechs in Oncology R&D. He is co-founder of the Biotherapy Development Association (Germany, 2001) and served on the Scientific Advisory Board of a German biotech company (2001-2003). He was the National Network Representative for The Netherlands in the Council of the European Association for Cancer Research (EACR), period 2013-2018, and received a  honorary EACR membership as of 2018.

From 2002-2006 Dr. Hendriks acted as Project Technical Assistant to the European Commission (DG Research) in the 5th Framework Programme (FP) overseeing 20 cancer-related EU-funded projects, served as expert evaluator in 5th, 6th, 7th FP and H2020 of the EU and acted as Administrative Manager for the FP6 CompuVac project (June 2008-October 2009). In addition, he assisted Austrian, Dutch, Italian, and Slovenian consortia in the preparation and submission of grant applications for the European Union’s 7th FP, H2020 and the Innovative Medicines Initiative 2.

He was successful in bringing the telomere targeting agent KML001 from early stage preclinical research to Phase I clinical studies (CCR 2008;14:4593-602) and is co-inventor of a US patent application (2009).

Hendriks Pharmaceutical Consulting is member of the Competence Network Life Science (www.conelis.org), an association of selected life science experts that provides top-tier consulting services to the pharmaceutical industry. It is a network of highly qualified and independent experts who can be contracted individually or as part of an interdisciplinary team.

Selected publications

Hendriks. H. et al., Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative, British Journal of Cancer, 2017.

Peters, GJ., Govaerts, A-S., Hendriks, H. for the EORTC-pharmacology and molecular mechanism group. The role of pharmacology in anticancer drug development, ADMET, 2018

#August

Thursday, August 16, 2018 at 14:00
Turku Centre for Biotechnology, 5th floor seminar room, BioCity B-staircase, Tykistökatu 6, Turku

Dr. Wah Ing Goh, the Agency for Science, Technology and Research (A*STAR) Microscopy Platform

Host: Camilo Guzman

 

Dear all,

We would like to invite you to a special seminar by   (https://www.a-star.edu.sg/imb/Tech-Platforms/IMB-Microscopy-Unit) in Singapore. Her seminar is entitled “The A*STAR Microscopy Platform and SingaScope – a microscopy core facility network for Singapore”. The seminar will take place in the TBC seminar room on the 5th Floor (Bio 5034a) and it is scheduled for Thursday 16th of August at 2:00 PM.

Dr. Goh is visiting the TBC as part of the “Job Shadowing International Program” of the Global BioImaging project and he will be shadowing our activities in bio imaging and promoting and active exchange between the Agency for Science, Technology and Research (A*STAR) and our Finnish ALM Node of Euro-BioImaging

For detailed information please see attached PDF file.

See you all there!

“Special seminar: The A*STAR Microscopy Platform and SingaScope – a microscopy core facility network for Singapore”

Dr. Wah Ing Goh, the Agency for Science, Technology and Research (A*STAR) Microscopy Platform

Host: Camilo Guzman

 

Dear all,

We would like to invite you to a special seminar by   (https://www.a-star.edu.sg/imb/Tech-Platforms/IMB-Microscopy-Unit) in Singapore. Her seminar is entitled “The A*STAR Microscopy Platform and SingaScope – a microscopy core facility network for Singapore”. The seminar will take place in the TBC seminar room on the 5th Floor (Bio 5034a) and it is scheduled for Thursday 16th of August at 2:00 PM.

Dr. Goh is visiting the TBC as part of the “Job Shadowing International Program” of the Global BioImaging project and he will be shadowing our activities in bio imaging and promoting and active exchange between the Agency for Science, Technology and Research (A*STAR) and our Finnish ALM Node of Euro-BioImaging

For detailed information please see attached PDF file.

See you all there!

#May

Wednesday, May 23, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Klaus Hedman, University of Helsinki

Host: Sisko Tauriainen

“MIKRO seminars: Hunting ancestral viruses in ancient tissue remains”

Klaus Hedman, University of Helsinki

Host: Sisko Tauriainen

Friday, May 18, 2018 at 13:00
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

FinLAS (Suomen koe-eläintieteen yhdistys ry) järjestää kevätseminaarin 18.5.2018 Turussa. Seminaari on tarkoitettu kaikille koe-eläinten parissa työskenteleville, koe-eläinalan ammattilaisille, tutkijoille ja opiskelijoille. Tapahtuma tarkempi ohjelma on tässä, ja kevätseminaarissa pääsemme kuulemaan koe-eläinkeskuksen johtajan Ulla-Marjut Jaakkolan läksiäisluennon.

Ilmoittautuminen: https://www.webropolsurveys.com/S/B9CD93BC3F165132.par

Lisätietoa: Emrah Yatkin (emryat@utu.fi)

“FinLAS-KEK kevätseminaari: Tiede ja tunteet”

FinLAS (Suomen koe-eläintieteen yhdistys ry) järjestää kevätseminaarin 18.5.2018 Turussa. Seminaari on tarkoitettu kaikille koe-eläinten parissa työskenteleville, koe-eläinalan ammattilaisille, tutkijoille ja opiskelijoille. Tapahtuma tarkempi ohjelma on tässä, ja kevätseminaarissa pääsemme kuulemaan koe-eläinkeskuksen johtajan Ulla-Marjut Jaakkolan läksiäisluennon.

Ilmoittautuminen: https://www.webropolsurveys.com/S/B9CD93BC3F165132.par

Lisätietoa: Emrah Yatkin (emryat@utu.fi)

Wednesday, May 16, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Matti Waris, University of Turku

Host: Ilkka Julkunen

“MIKRO seminars: Host biomarkers of respiratory virus infections”

Matti Waris, University of Turku

Host: Ilkka Julkunen

Friday, May 11, 2018 at 12:00
pub3 auditorium, Publicum, Assistentinkatu 7, Turku

Finnish Society for Bioinformatics is arranging a yearly Bioinformatics day, and the program includes lectures, poster session and workshops. The topics of the lectures are dealing with current bioinformatics research including both biosciences and computational modeling. This event gathers together people working with bioinformatics, both from universities and from companies around Finland.

Program of the event is available here.

Registration to the event from here.

“Bioinformatics day 2018”

Finnish Society for Bioinformatics is arranging a yearly Bioinformatics day, and the program includes lectures, poster session and workshops. The topics of the lectures are dealing with current bioinformatics research including both biosciences and computational modeling. This event gathers together people working with bioinformatics, both from universities and from companies around Finland.

Program of the event is available here.

Registration to the event from here.

Wednesday, May 9, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Ilkka Julkunen, University of Turku

Host: Laura Kakkola

“MIKRO seminars: Human macrophages and DCs, receptors, signaling and activation of innate immunity”

Ilkka Julkunen, University of Turku

Host: Laura Kakkola

Monday, May 7, 2018 at 12:00
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Prof. John Lemasters
GlaxoSmithKline Distinguished Endowed Chair
Director, Center for Cell Death, Injury & Regeneration
Departments of Drug Discovery & Biomedical Sciences and Biochemistry & Molecular Biology
Medical University of South Carolina, USA

Host: Eeva-Liisa Eskelinen (eeva-liisa.eskelinen@utu.fi)
In case you wish to meet with Prof. Lemasters, please contact the host.

 

Dr. Lemasters’ research interests include the cellular and molecular mechanisms underlying toxic, hypoxic and ischemia-reperfusion injury to liver and heart. His laboratory applies new techniques of laser scanning confocal and multiphoton microscopy to characterize the physiology of single living cells, including the assessment of ion homeostasis, chelatable iron, mitochondrial function, electrical potentials, oxygen and nitrogen free radical formation, membrane permeability and other biochemical parameters during the pathogenesis of lethal cell injury.

 Selected publications

DeHart DN, Fang D, Heslop K, Li L, Lemasters JJ, Maldonado EN. Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. Biochem Pharmacol. 2018 Feb;148:155-162. doi: 10.1016/j.bcp.2017.12.022. Epub 2017 Dec 28.

Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ. ATP/ADP turnover and import of glycolytic ATP into mitochondria in cancer cells is independent of the adenine nucleotide translocator. J Biol Chem. 2017 Oct 13;292(41):16969. doi: 10.1074/jbc.A116.734814.

Teplova VV, Kruglov AG, Kovalyov LI, Nikiforova AB, Fedotcheva NI, Lemasters JJ. Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria. J Bioenerg Biomembr. 2017 Jun;49(3):253-264. doi: 10.1007/s10863-017-9713-0. Epub 2017 May 6.

Liu Q, H Rehman, Y Krishnasamy, RG Schnellmann, JJ Lemasters and Z Zhong. Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice. J Hepatol 2015, 63:68-74.

 

“Special seminar: Types and Initiators of Mitochondrial Autophagy (Mitophagy)”

Prof. John Lemasters
GlaxoSmithKline Distinguished Endowed Chair
Director, Center for Cell Death, Injury & Regeneration
Departments of Drug Discovery & Biomedical Sciences and Biochemistry & Molecular Biology
Medical University of South Carolina, USA

Host: Eeva-Liisa Eskelinen (eeva-liisa.eskelinen@utu.fi)
In case you wish to meet with Prof. Lemasters, please contact the host.

 

Dr. Lemasters’ research interests include the cellular and molecular mechanisms underlying toxic, hypoxic and ischemia-reperfusion injury to liver and heart. His laboratory applies new techniques of laser scanning confocal and multiphoton microscopy to characterize the physiology of single living cells, including the assessment of ion homeostasis, chelatable iron, mitochondrial function, electrical potentials, oxygen and nitrogen free radical formation, membrane permeability and other biochemical parameters during the pathogenesis of lethal cell injury.

 Selected publications

DeHart DN, Fang D, Heslop K, Li L, Lemasters JJ, Maldonado EN. Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. Biochem Pharmacol. 2018 Feb;148:155-162. doi: 10.1016/j.bcp.2017.12.022. Epub 2017 Dec 28.

Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ. ATP/ADP turnover and import of glycolytic ATP into mitochondria in cancer cells is independent of the adenine nucleotide translocator. J Biol Chem. 2017 Oct 13;292(41):16969. doi: 10.1074/jbc.A116.734814.

Teplova VV, Kruglov AG, Kovalyov LI, Nikiforova AB, Fedotcheva NI, Lemasters JJ. Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria. J Bioenerg Biomembr. 2017 Jun;49(3):253-264. doi: 10.1007/s10863-017-9713-0. Epub 2017 May 6.

Liu Q, H Rehman, Y Krishnasamy, RG Schnellmann, JJ Lemasters and Z Zhong. Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice. J Hepatol 2015, 63:68-74.

 

Friday, May 4, 2018 at 13:15
Kurssalen, ÅAU Cell Biology, Biocity 2nd floor, Tykistökatu 6, Turku

Nicholas Kurniawan (PhD; assistant professor in biomedical engineering) and Aref Saberi (BSc) from the Eindhoven University of Technology (TU/e) will present their research as well as research and study opportunities available at their university next week at ÅAU Cell Biology.

Host: prof. Cecilia Sahlgren

13.15-14:00 Dr. Nicholas Kurniawan, Assistant professor in biomedical engineering, Eindhoven University of Technology (TU/e): Mechanobiology and tissue engineering

Dr. Kurniawan will present his research focused on the biophysical and mechanobiological aspects of cell-matrix interactions and related applications in regenerative medicine. In his research he combines expertise in biopolymer physics, cell biomechanics, and cytoskeletal rheology.

14:15-15:00 Aref Saberi, Eindhoven University of Technology (TU/e): Research activities and MSc programmes at Eindhoven University of Technology

An overview of research activities, educational programmes and student life at TU/e. The presentation is directed especially at students and researchers interested in doing an exchange abroad.

Kurniawan and Saberi will also give a lecture on stem cells and mechanosignaling on the ÅAU Stem cells course (223001.0) at 10-12 on the same day (in Kurssalen). Everyone interested is welcome to take part in the lecture as well.

“Special seminar: Mechanobiological research and study opportunities at Eindhoven University of Technology”

Nicholas Kurniawan (PhD; assistant professor in biomedical engineering) and Aref Saberi (BSc) from the Eindhoven University of Technology (TU/e) will present their research as well as research and study opportunities available at their university next week at ÅAU Cell Biology.

Host: prof. Cecilia Sahlgren

13.15-14:00 Dr. Nicholas Kurniawan, Assistant professor in biomedical engineering, Eindhoven University of Technology (TU/e): Mechanobiology and tissue engineering

Dr. Kurniawan will present his research focused on the biophysical and mechanobiological aspects of cell-matrix interactions and related applications in regenerative medicine. In his research he combines expertise in biopolymer physics, cell biomechanics, and cytoskeletal rheology.

14:15-15:00 Aref Saberi, Eindhoven University of Technology (TU/e): Research activities and MSc programmes at Eindhoven University of Technology

An overview of research activities, educational programmes and student life at TU/e. The presentation is directed especially at students and researchers interested in doing an exchange abroad.

Kurniawan and Saberi will also give a lecture on stem cells and mechanosignaling on the ÅAU Stem cells course (223001.0) at 10-12 on the same day (in Kurssalen). Everyone interested is welcome to take part in the lecture as well.

#April

Wednesday, April 25, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Tapio Lönnberg, Turku Centre for Biotechnology

Host: Raine Toivonen

“MIKRO seminars: Single-cell transcriptomics and T cell fate decisions”

Tapio Lönnberg, Turku Centre for Biotechnology

Host: Raine Toivonen

Wednesday, April 18, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Juha Vuononvirta, Imperial College of London

Host: Alex-Mikael Barkoff

“CANCELLED: MIKRO seminars: In vivo imaging of neutrophilic inflammation in murine lung”

Juha Vuononvirta, Imperial College of London

Host: Alex-Mikael Barkoff

Wednesday, April 11, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Minna Poranen, University of Helsinki

Host: Veijo Hukkanen

“MIKRO seminars: Genome replication by double-stranded RNA viruses and phages: from molecular mechanisms to RNAi applications”

Minna Poranen, University of Helsinki

Host: Veijo Hukkanen

Wednesday, April 4, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Arno Hänninen, Univeristy of Turku

Host: Raine Toivonen

“MIKRO seminars: Proteomics approach to study gut microbia and its relevance in type 1 diabetes”

Arno Hänninen, Univeristy of Turku

Host: Raine Toivonen

#March

Wednesday, March 28, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Manu Tamminen, University of Turku

Host: Kirsi Gröndahl-Yli-Hannuksela

“MIKRO seminars: Understanding antibiotic resistance using next-generation DNA sequencing”

Manu Tamminen, University of Turku

Host: Kirsi Gröndahl-Yli-Hannuksela

Wednesday, March 21, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Karolina Louvanto, University Hospital of Turku, University of Turku

Host: Stina Syrjänen

“MIKRO seminars: HLA-G role in the natural history of HPV infection”

Karolina Louvanto, University Hospital of Turku, University of Turku

Host: Stina Syrjänen

Wednesday, March 7, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Jaana Vuopio, University of Turku

Host: to be announced

“MIKRO seminars: Switching dynamics of MRSA – from healthcare to community”

Jaana Vuopio, University of Turku

Host: to be announced

#February

Wednesday, February 28, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Tiina Nokireki, Finnish Food Safety Authority

Host: Tytti Vuorinen

 

“MIKRO seminars: Bat rabies in Turku area”

Tiina Nokireki, Finnish Food Safety Authority

Host: Tytti Vuorinen

 

Thursday, February 22, 2018 at 15:30
Auditorium Beta, ICT-building, Joukahaisenkatu 3-5, Turku

BioCity research programme seminar, organized jointly by LIFESPAN and Receptor Programme and Turku Brain and Mind Center

 

Prof. Ulrik Gether, University of Copenhagen
The dopamine transporter: a key player in psychostimulant addiction and dopaminergic pathologies

Dr. Volker Eulenburg, University Hospital Leipzig, Clinics for Anaesthesiology and Intensive Care Medicine
Glycine transporter function in retina and dorsal horn – GlyT1 as a major regulator of glycine dependent neurotransmission

Host: Mika Scheinin (mschein@utu.fi)

Coffee/tea will be served at 15:00

“LIFESPAN and Receptor programme seminar: Ulrik Gether and Volker Eulenberg”

BioCity research programme seminar, organized jointly by LIFESPAN and Receptor Programme and Turku Brain and Mind Center

 

Prof. Ulrik Gether, University of Copenhagen
The dopamine transporter: a key player in psychostimulant addiction and dopaminergic pathologies

Dr. Volker Eulenburg, University Hospital Leipzig, Clinics for Anaesthesiology and Intensive Care Medicine
Glycine transporter function in retina and dorsal horn – GlyT1 as a major regulator of glycine dependent neurotransmission

Host: Mika Scheinin (mschein@utu.fi)

Coffee/tea will be served at 15:00

Wednesday, February 7, 2018 at 11:00
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Minna Niemelä, Turku Centre for Biotechnology

Host: Raine Toivonen

“MIKRO seminars: Genomics services available for biomedical research at FFGC”

Minna Niemelä, Turku Centre for Biotechnology

Host: Raine Toivonen

#January

Wednesday, January 31, 2018 at 11:15
Dentalia, Dent 1, Lemminkäisenkatu 2, Turku

This seminar is cancelled

Tapio Lönnberg, Turku Centre for Biotechnology

Host: Raine Toivonen

“CANCELLED: MIKRO seminars: Single-cell transcriptomics and T cell fate decisions”

This seminar is cancelled

Tapio Lönnberg, Turku Centre for Biotechnology

Host: Raine Toivonen

Wednesday, January 24, 2018 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Manu Tamminen, University of Turku

Host: Kirsi Gröndahl-Yli-Hannuksela

“CANCELLED: MIKRO seminars: Understanding antibiotic resistance using next-generation DNA sequencing”

Manu Tamminen, University of Turku

Host: Kirsi Gröndahl-Yli-Hannuksela

#December

Thursday, December 21, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. John Marshall, Barts Cancer Institute, London, UK

“FoS: Development of imaging and therapy of cancer by targeting integrin alpha-v beta-6”

Prof. John Marshall, Barts Cancer Institute, London, UK

Host: Johanna Ivaska

 

Prof. John Marshall has been studying the biology of tumour invasion for the last 25 years with a particular interest in the contributions made by the principal cell-matrix adhesion molecules called integrins. Prof Marshall’s group have identified integrin αvβ6, an epithelial-specific integrin not detectable on most normal tissues, as an important new therapeutic target in many cancers. In addition to understanding the function of the αvβ6 receptor in cancer, his group recently launched a clinical trial, in collaboration with Imanova to test the efficacy of an αvβ6-specific peptide for imaging solid cancers.

Selected publications

Raab-Westphal S, Marshall JF, Goodman SL. Integrins as Therapeutic Targets: Successes and Cancers. 2017 Cancers (Basel) 9(9).

Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RM, Kao YV, Saxena SA, Romain A, Costa-Guerra JA, Violette S, Itamochi H, Ghaem-Maghami S, Vallath S, Marshall JF, Maher J. Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells. (2017) Mol Ther. 25(1):259-273

Moore KM, Thomas GJ, Duffy SW et al. Therapeutic targeting of integrin αvβ6 in breast cancer. (2014) J Natl Cancer Inst vol. 106, (8)

Allen MD, Thomas GJ, Clark S et al. Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence. (2014) Clin Cancer Res (2) 344-357

Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF. Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion. (2011) Oncogene 30(12):1422-35

Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR and Marshall JF. High resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin αvβ6. (2010) J Path. 222:52-63

Thursday, December 14, 2017 at 16:00
Lambda auditorium, ICT building, Joukahaisenkatu 3-5, Turku

You are warmly welcome to the Turku Cancer Research Society’s Christmas Seminar!

Topic of the seminar will be colorectal cancer and we have speakers presenting both basic research and clinical aspects.

Program
16.00 Welcome
PhD Thesis of the Year Award
-Break for snacks and drinks-
17.00 Annika Ålgars (Turku University Hospital)
“An oncologists perspective to CRC and a glimpse into own research data”
17.30 Diana Toivola (Åbo Akademi University)
“Colorectal cancer – Keratins in disease mechanism and disease modeling”
17.50 Elli Narvi (University of Turku)
“Response to EGFR inhibition plus oxaliplatin is determined by the sequence of administration in colorectal cancer”

“Turku Cancer Research Society’s Christmas Seminar”

You are warmly welcome to the Turku Cancer Research Society’s Christmas Seminar!

Topic of the seminar will be colorectal cancer and we have speakers presenting both basic research and clinical aspects.

Program
16.00 Welcome
PhD Thesis of the Year Award
-Break for snacks and drinks-
17.00 Annika Ålgars (Turku University Hospital)
“An oncologists perspective to CRC and a glimpse into own research data”
17.30 Diana Toivola (Åbo Akademi University)
“Colorectal cancer – Keratins in disease mechanism and disease modeling”
17.50 Elli Narvi (University of Turku)
“Response to EGFR inhibition plus oxaliplatin is determined by the sequence of administration in colorectal cancer”

Wednesday, December 13, 2017 at 11:15
Dentalia, Dent 1, Lemminkäisenkatu 2, Turku

MIKRO Seminars of Infection Biology and Infectious Diseases

Tuija Kantala, University of Turku

Host: Matti Waris

“MIKRO seminars: Hepatitis E virus in Finland in pigs and humans”

MIKRO Seminars of Infection Biology and Infectious Diseases

Tuija Kantala, University of Turku

Host: Matti Waris

Friday, December 1, 2017 at 14:00
Turku Centre for Biotechnology, 5th floor seminar room, BioCity B-staircase, Tykistökatu 6, Turku

Adjunct Prof. Timo Myöhänen, Drug Research Program, University of Helsinki

Host: Jukka Westermarck

Timo Myöhänen got his PhD (Pharmacology) in 2008 at University of Kuopio, and thereafter had post-doctoral visits in University of Antwerp (Belgium) and Georgetown University (Washington DC, USA) in 2010 and 2012. Dr. Myöhänen established his research group into Division of Pharmacology and Pharmacotherapy in University of Helsinki in 2011, got docentship in pharmacology in 2012 and is currently holding an Academy of Finland Research Fellow position. His research has focused on impact of a serine protease, prolyl oligopeptidase (PREP) and its pharmacological inhibition, on aggregation and toxicity of alpha-synuclein, a possible key player in cellular toxicity on Parkinson’s disease. Recent studies of Myöhänen lab have shown that PREP inhibitors can reduce the aggregation of alpha-synuclein and also enhance its clearance from cells by accelerating autophagy.

 

Lab website: http://blogs.helsinki.fi/prepinneuro/

“Special Seminar: Prolyl oligopeptidase (PREP) – a novel regulator for PP2A”

Adjunct Prof. Timo Myöhänen, Drug Research Program, University of Helsinki

Host: Jukka Westermarck

Timo Myöhänen got his PhD (Pharmacology) in 2008 at University of Kuopio, and thereafter had post-doctoral visits in University of Antwerp (Belgium) and Georgetown University (Washington DC, USA) in 2010 and 2012. Dr. Myöhänen established his research group into Division of Pharmacology and Pharmacotherapy in University of Helsinki in 2011, got docentship in pharmacology in 2012 and is currently holding an Academy of Finland Research Fellow position. His research has focused on impact of a serine protease, prolyl oligopeptidase (PREP) and its pharmacological inhibition, on aggregation and toxicity of alpha-synuclein, a possible key player in cellular toxicity on Parkinson’s disease. Recent studies of Myöhänen lab have shown that PREP inhibitors can reduce the aggregation of alpha-synuclein and also enhance its clearance from cells by accelerating autophagy.

 

Lab website: http://blogs.helsinki.fi/prepinneuro/

#November

Thursday, November 30, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Robert Viger, Laval University, Quebec, Canada

“FoS: Understanding gonadal development and function: what we can learn from transcription studies”

Prof. Robert Viger, Laval University, Quebec, Canada

Hosts: Nafis Rahman and Jorma Toppari

Wednesday, November 29, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Anniina Rintala, University of Turku

Host: Jaana Vuopio

“MIKRO: Gut microbes in the prevention and onset of metabolic disorders”

Anniina Rintala, University of Turku

Host: Jaana Vuopio

Tuesday, November 28, 2017 at 13:15
PET centre seminar room, Kiinamyllynkatu 4-8, Turku

Florian Freudenberg, Translational Psychiatry Laboratory, Department of Psychiatry, Frankfurt University Hospital

Host: Michael Courtney

“Special Seminar: Targeted disruption of NOS-I PDZ interactions using viral gene transfer: Implications for psychiatric disorders”

Florian Freudenberg, Translational Psychiatry Laboratory, Department of Psychiatry, Frankfurt University Hospital

Host: Michael Courtney

Thursday, November 23, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Duane A. Compton, Geisel School of Medicine at Dartmouth, Hanover, USA

“FoS: Causes and consequences of chromosomal instability in cancer”

Prof. Duane A. Compton, Geisel School of Medicine at Dartmouth, Hanover, USA

Host: Sofia Pruikkonen

Thursday, November 16, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Andrew Cant, Institute of Cellular Medicine, University of Newcastle, UK

“FoS: Primary immunodeficiency: New understandings and new treatments”

Prof. Andrew Cant, Institute of Cellular Medicine, University of Newcastle, UK

Host: Ville Peltola

Wednesday, November 15, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

MIKRO Seminars of Infection Biology and Infectious Diseases

Johanna Ivaska, University of Turku

Host: Raine Toivonen

“MIKRO Seminars: Imaging cancer cell invasion and the regulation of pluripotency”

MIKRO Seminars of Infection Biology and Infectious Diseases

Johanna Ivaska, University of Turku

Host: Raine Toivonen

Wednesday, November 8, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

MIKRO Seminars of Infection Biology and Infectious Diseases

Ausra Domanska, University of Helsinki

Host: Petri Susi

“MIKRO Seminars: High resolution structure of human parechovirus 3 in complex with fabs from a neutralizing antibody”

MIKRO Seminars of Infection Biology and Infectious Diseases

Ausra Domanska, University of Helsinki

Host: Petri Susi

Tuesday, November 7, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Mihai Netea, Faculty of Medical Sciences, Radboud University, Nijmegen, Netherlands

“FoS: Trained immunity: adaptation and memory in innate immune responses”

Prof. Mihai Netea, Faculty of Medical Sciences, Radboud University, Nijmegen, Netherlands:

Host: Riitta Lahesmaa ( rilahes@utu.fi )

Monday, November 6, 2017 at 00:00

SmartBIO Annual Meeting will be arranged on Monday November 6th 2017 in Kankaisten Linna (Kankaistentie 57, 21250 Masku). SmartBIO is one of the seven BioCity Turku Research Programmes for the years 2016-2020. In this one-day meeting the scientific program (all in English) includes two invited lecturers from industry partners and fifteen-minute talks from SmatBIO team members.

The registration is now open until Oct 29th https://link.webropolsurveys.com/S/6116624FED0228CAYou can also find the registration from the SmartBIO web pages, together with the tentative program and more detailed information.
http://smartbio.fi/registration-smartbio-annual-meeting-2017-open

If you have any questions regarding the meeting please don’t hesitate to contact Maija Lespinasse (miholm@utu.fi).

“SmartBIO Annual Meeting”

SmartBIO Annual Meeting will be arranged on Monday November 6th 2017 in Kankaisten Linna (Kankaistentie 57, 21250 Masku). SmartBIO is one of the seven BioCity Turku Research Programmes for the years 2016-2020. In this one-day meeting the scientific program (all in English) includes two invited lecturers from industry partners and fifteen-minute talks from SmatBIO team members.

The registration is now open until Oct 29th https://link.webropolsurveys.com/S/6116624FED0228CAYou can also find the registration from the SmartBIO web pages, together with the tentative program and more detailed information.
http://smartbio.fi/registration-smartbio-annual-meeting-2017-open

If you have any questions regarding the meeting please don’t hesitate to contact Maija Lespinasse (miholm@utu.fi).

Friday, November 3, 2017 at 10:00
Ministeri auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Patrick Lewis, Reading School of Pharmacy, Reading, United Kingdom

Host: Eleanor Coffey

“Special Seminar: LRRK2 and macroautophagy – reading between the hieroglyphs”

Patrick Lewis, Reading School of Pharmacy, Reading, United Kingdom

Host: Eleanor Coffey

Thursday, November 2, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Michael Hottiger, Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland

“FoS: Uncovering the functional role of protein ADP-ribosylation on the proteome-wide level”

Prof. Michael Hottiger, Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland:

Host: Arto Pulliainen

 

The Hottiger-laboratory studies molecular regulatory mechanisms of inflammation, with special focus on the role of post-translation modifications in inflammatory signaling. They have contributed to the identification of protein ADP-ribosylation as a crucial process in the cellular response to detrimental stimuli, be it through genotoxicity, oxidative or metabolic stress, or excessive inflammation. Their current work focuses on the following questions: (i) Are ADP-ribosylation patterns cell-type specific or stimulus-specific, i.e. are there specific patterns that are associated with specific cell-physiological conditions? (ii) What are the modifiers (writer, binders, erasers) involved in those patterns? How can we specifically interfere with their activity to modulate the patterns? (iii) What are the regulatory mechanisms in ADP-ribosylation? How is the type and quantity of ADP-ribosylation patterns regulated? (iv) What are the downstream events of ADP-ribosylation, i.e. how does ADP-ribosylation alter the function of specific proteins and what is the effect on cell physiology? Most recently, the Hottiger-laboratory has studied the patterns of ADP-ribosylation using new systems biology approaches such as ADP-ribose specific high-resolution and quantitative mass spectrometry.

 

Website: http://www.dmmd.uzh.ch/en/research/hottiger.html

 

Selected publications:

 

Bisceglie L, Bartolomei G and Hottiger MO (2017) ADP-ribose-specific chromatin-affinity purification for investigating genome-wide or locus-specific chromatin ADP-ribosylation. Nature Protocols Sep;12(9):1951-1961.

 

Bilan V, Selevsek N, Kistemaker HAV, Abplanalp J, Feurer R, Filippov DV and Hottiger MO (2017) New quantitative mass spectrometry approaches reveal different ADP-ribosylation phases dependent on the levels of oxidative stress. Molecular & Cellular Proteomics May;16(5):949-958.

 

Bilan V, Leutert M, Nanni P, Panse C, Hottiger MO (2017) Combining Higher-Energy collision dissociation and electron-transfer/higher energy collision dissociation fragmentation in a product-dependent manner confidently assigns proteomewide ADP-ribose acceptor Sites. Analytical Chemistry Feb 7;89(3):1523-1530.

 

Martello R, Leutert M, Jungmichel S, Bilan V, Larsen SC, Young C, Hottiger MO and Nielsen ML (2016) Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue. Nature Communications Sep 30;7:12917. doi:

 

Leutert M, Pedrioli DML and Hottiger MO (2016) Identification of PARP-specific ADP-ribosylation targets reveals a regulatory function for ADP-ribosylation in transcription elongation. Molecular Cell Jul 21;63(2):181-183.

 

Hottiger MO (2015) SnapShot: ADP-ribosylation signaling. Molecular Cell Jun 18;58(6):1134-1134.e1.

#October

Thursday, October 26, 2017 at 15:00
Wikgren lecture room, BioCity 1st floor, Tykistökatu 6, Turku

Associate Professor Sven Nelander, Uppsala University, Uppsala, Sweden

 Receptor Program Seminar

Host: Jukka Westermarck (jukwes(at)utu.fi)

****
Sven Nelander is an Associate Professor at the Department of Immunology, Genetics and Pathology and Science for Life Laboratory at Uppsala University. His research group focuses on integrated approaches to cancer intervention, combining computational and experimental methods. A key diagnostic focus is GBM. Sven Nelander received his PhD in 2005 at the University of Gothenburg and trained as a postdoc at Memorial Sloan Kettering Cancer Center, NY (Sander lab). He joined Uppsala University in 2012.

“Targeting tumor heterogeneity: multi-genomic modeling of glioblastoma drug response using an open-access library of patient-derived cells”

Associate Professor Sven Nelander, Uppsala University, Uppsala, Sweden

 Receptor Program Seminar

Host: Jukka Westermarck (jukwes(at)utu.fi)

****
Sven Nelander is an Associate Professor at the Department of Immunology, Genetics and Pathology and Science for Life Laboratory at Uppsala University. His research group focuses on integrated approaches to cancer intervention, combining computational and experimental methods. A key diagnostic focus is GBM. Sven Nelander received his PhD in 2005 at the University of Gothenburg and trained as a postdoc at Memorial Sloan Kettering Cancer Center, NY (Sander lab). He joined Uppsala University in 2012.

Thursday, October 26, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Mads Gyrd-Hansen, Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK:

Host: Annika Meinander (annika.meinander(at)abo.fi) (Receptor)
**************

The Gyrd-Hansen laboratory studies molecular mechanisms governing pro-inflammatory signalling during innate immune responses. Through this, they aim to understand the molecular mechanisms that on one hand protect against pathogens, but that also contribute to chronic inflammation, tumor development and cancer progression. A central focus of the lab is to elucidate the role and regulation of non-degradative ubiquitin modifications in these processes. Ultimately, they aim to identify ubiquitin-handling factors that can be targeted to modulate inflammation and antagonize cancer. Professor Gyrd-Hansen’s recent work has focused on the role of Met1-linked ubiquitin chains (also known as linear ubiquitin chains) in inflammatory signaling. These chains are generated by the Linear UBiquitin Assembly Complex (LUBAC), which is a key component of inflammatory signaling pathways, including those activated downstream of the cytoplasmic PRRs NOD1 and NOD2 that serve as sensors for intracellular bacteria. They have uncovered and characterised several factors that regulate the function of LUBAC in signaling. Future work in the group will focus on elucidating the function, regulation and interplay of individual ubiquitin chain types (of which there are at least eight) in the cellular response to infection.

Website: http://www.ludwig.ox.ac.uk/mads-gyrd-hansen

Selected publications:

Gyrd-Hansen M. All roads lead to ubiquitin. Cell Death Differ. 2017 Jul;24(7):1135-1136. doi: 10.1038/cdd.2017.93.

Elliott PR, Leske D, Hrdinka M, Bagola K, Fiil BK, McLaughlin SH, Wagstaff J, Volkmar N, Christianson JC, Kessler BM, Freund SM, Komander D, Gyrd-Hansen M. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Mol Cell. 2016 Sep 15;63(6):990-1005. doi: 10.1016/j.molcel.2016.08.001.

Hrdinka M, Fiil BK, Zucca M, Leske D, Bagola K, Yabal M, Elliott PR, Damgaard RB, Komander D, Jost PJ, Gyrd-Hansen M. CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling. Cell Rep. 2016 Mar 29;14(12):2846-58. doi: 10.1016/j.celrep.2016.02.062.

Fiil BK, Gyrd-Hansen M. Met1-linked ubiquitination in immune signalling. FEBS J. 2014 Oct;281(19):4337-50. doi: 10.1111/febs.12944.

Damgaard RB, Fiil BK, Speckmann C, Yabal M, zur Stadt U, Bekker-Jensen S, Jost PJ, Ehl S, Mailand N, Gyrd-Hansen M. Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med. 2013 Aug;5(8):1278-95. doi: 10.1002/emmm.201303090.

Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M. OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol Cell. 2013 Jun
27;50(6):818-830. doi: 10.1016/j.molcel.2013.06.004.

Damgaard RB, Nachbur U, Yabal M, Wong WW, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ, Gyrd-Hansen M. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012 Jun 29;46(6):746-58. doi: 10.1016/j.molcel.2012.04.014.

“FoS: Ubiquitin signalling in inflammation”

Prof. Mads Gyrd-Hansen, Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK:

Host: Annika Meinander (annika.meinander(at)abo.fi) (Receptor)
**************

The Gyrd-Hansen laboratory studies molecular mechanisms governing pro-inflammatory signalling during innate immune responses. Through this, they aim to understand the molecular mechanisms that on one hand protect against pathogens, but that also contribute to chronic inflammation, tumor development and cancer progression. A central focus of the lab is to elucidate the role and regulation of non-degradative ubiquitin modifications in these processes. Ultimately, they aim to identify ubiquitin-handling factors that can be targeted to modulate inflammation and antagonize cancer. Professor Gyrd-Hansen’s recent work has focused on the role of Met1-linked ubiquitin chains (also known as linear ubiquitin chains) in inflammatory signaling. These chains are generated by the Linear UBiquitin Assembly Complex (LUBAC), which is a key component of inflammatory signaling pathways, including those activated downstream of the cytoplasmic PRRs NOD1 and NOD2 that serve as sensors for intracellular bacteria. They have uncovered and characterised several factors that regulate the function of LUBAC in signaling. Future work in the group will focus on elucidating the function, regulation and interplay of individual ubiquitin chain types (of which there are at least eight) in the cellular response to infection.

Website: http://www.ludwig.ox.ac.uk/mads-gyrd-hansen

Selected publications:

Gyrd-Hansen M. All roads lead to ubiquitin. Cell Death Differ. 2017 Jul;24(7):1135-1136. doi: 10.1038/cdd.2017.93.

Elliott PR, Leske D, Hrdinka M, Bagola K, Fiil BK, McLaughlin SH, Wagstaff J, Volkmar N, Christianson JC, Kessler BM, Freund SM, Komander D, Gyrd-Hansen M. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Mol Cell. 2016 Sep 15;63(6):990-1005. doi: 10.1016/j.molcel.2016.08.001.

Hrdinka M, Fiil BK, Zucca M, Leske D, Bagola K, Yabal M, Elliott PR, Damgaard RB, Komander D, Jost PJ, Gyrd-Hansen M. CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling. Cell Rep. 2016 Mar 29;14(12):2846-58. doi: 10.1016/j.celrep.2016.02.062.

Fiil BK, Gyrd-Hansen M. Met1-linked ubiquitination in immune signalling. FEBS J. 2014 Oct;281(19):4337-50. doi: 10.1111/febs.12944.

Damgaard RB, Fiil BK, Speckmann C, Yabal M, zur Stadt U, Bekker-Jensen S, Jost PJ, Ehl S, Mailand N, Gyrd-Hansen M. Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med. 2013 Aug;5(8):1278-95. doi: 10.1002/emmm.201303090.

Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M. OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol Cell. 2013 Jun
27;50(6):818-830. doi: 10.1016/j.molcel.2013.06.004.

Damgaard RB, Nachbur U, Yabal M, Wong WW, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ, Gyrd-Hansen M. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012 Jun 29;46(6):746-58. doi: 10.1016/j.molcel.2012.04.014.

Wednesday, October 25, 2017 at 10:15
Ministeri auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

For symposium program, click here.

Register latest Oct 22nd at: https://link.webropolsurveys.com/S/C1C0722937CB171E

“SyMMyS Symposium: New insights into Type 1 diabetes and regulation of immune responses”

For symposium program, click here.

Register latest Oct 22nd at: https://link.webropolsurveys.com/S/C1C0722937CB171E

Thursday, October 12, 2017 at 12:00
Dentalia Auditorium (Arje Scheinin), 2nd floor, Lemminkäisenkatu 2, Turku

Prof. Ville Kaila, Department of Chemistry, Technical University of Munich, Germany

“FoS: Exploring molecular mechanisms in biological energy conversion”

Prof. Ville Kaila, Department of Chemistry, Technical University of Munich, Germany

Host: Paula Mulo

Description of research:

The research of Prof. Ville Kaila is focused on enzymatic and biomimetic catalysts for energy conversion. These processes are studied in respiratory and photosynthetic enzymes, but also in non-biological systems such as water-splitting molecular catalysts and molecular capsules. Prof. Kaila applies and develops powerful computational methodology ranging from ab initio quantum chemical techniques, hybrid quantum mechanics/classical mechanics (QM/MM) and subsystems methods, to large-scale classical molecular dynamics simulations, free-energy and continuum approaches.

Prof. Kaila will describe his recent work on the respiratory Complex I, and he will discuss how combination of experiments and multi-scale molecular simulations can provide a powerful methodology to obtain a molecular-level understanding of the structure, energetics, and dynamics of energy-capturing proteins, and how such methods can further be employed to engineer and design new proteins with desired target functions.

Selected publications:

Sharma V, Belevich G, Gamiz-Hernandez AP, Róg T, Vattulainen I, Wikström M, Hummer G, Kaila VRI (2015) Redox-Induced Activation of the Proton Pump in the Respiratory Complex I Proc. Natl. Acad. Sci. USA 112:11571-11576.

Kmita K, Wirth C, Warnau J, Guerrero-Castillo S, Hunte C, Hummer G, Kaila VRI, Zwicker K, Brandt U, Zickermann V. (2015) Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.  Proc. Natl. Acad. Sci. USA 112:5685-5690.

Boczek EE, Reefschläger LG, Dehling M, Struller T, Häusler E, Seidl A, Kaila VRI, Buchner J (2014) Conformational processing of oncogenic v-Src kinase by Hsp90. Proc. Natl. Acad. Sci. USA 112: E3189-3198.

Wikström M, Sharma V, Kaila VRI, Hosler J, Hummer G (2015) New perspectives on proton pumping in cellular respiration. Chem. Rev. 115, 2196-2221.

Kaila VRI , Schotte F, Hyun S-C, Hummer G, Anfinrud PA (2014) Reconciling contradictions in time-resolved x-ray structures of early intermediates in the photocycle of photoactive yellow protein Nature Chem 6:258-259.

Kaila VRI ,  Wikström M, Hummer G (2014) Electrostatics, Hydration, and Proton Transfer Dynamics in the Membrane Domain of Respiratory Complex I. Proc Natl Acad Sci USA 111, 6988-6993.

Schotte F, Hyun S-C,  Kaila VRI, Kamikubo H, Dashdorja N, Henry E, Graber T, Henning R, Wulff M, Hummer G, Kataoka M, Anfinruda PA (2012) Picosecond Photobiology: Watching a Signaling Protein Function in Real Time via Time-resolved Laue Crystallography. Proc Natl Acad Sci USA 109, 19256-19261.

Thursday, October 12, 2017 at 10:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Robert Lyle, Oslo University Hospital and University of Oslo, Norway

Host: Riikka Lund

“Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD”

Robert Lyle, Oslo University Hospital and University of Oslo, Norway

Host: Riikka Lund

Wednesday, October 11, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Päivi Saavalainen, University of Helsinki
Host: Jorma Ilonen

“MIKRO Seminars of Infection Biology and Infectious Diseases: TBA”

Päivi Saavalainen, University of Helsinki
Host: Jorma Ilonen

Tuesday, October 10, 2017 at 10:00
Auditorium Beta, ICT-building, Joukahaisenkatu 3-5, Turku

Program

10.00     Coffee
10.15     Professor Noel Morgan, University of Exeter Medical School, UK: “Type 1 diabetes; evidence for disease heterogeneity”
11.00     Dr Sarah Richardson, University of Exeter Medical School, UK: “Is Type 1 Diabetes ‘Going Viral’?”
11.45     Dr. Mark Russell, Islet Biology Exeter, UK: “JAK/STAT Signalling in the Pathogenesis of Type 1 Diabetes”

Organised by:

The Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology
Turku Centre for LIFESPAN Research

 

“MINISYMPOSIUM: Molecular Mechanisms of Type 1 Diabetes”

Program

10.00     Coffee
10.15     Professor Noel Morgan, University of Exeter Medical School, UK: “Type 1 diabetes; evidence for disease heterogeneity”
11.00     Dr Sarah Richardson, University of Exeter Medical School, UK: “Is Type 1 Diabetes ‘Going Viral’?”
11.45     Dr. Mark Russell, Islet Biology Exeter, UK: “JAK/STAT Signalling in the Pathogenesis of Type 1 Diabetes”

Organised by:

The Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology
Turku Centre for LIFESPAN Research

 

Thursday, October 5, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Antti Poso, University of Eastern Finland, School of Pharmacy; Distinguished Guest Professor at the University of Tübingen in Germany

Host: Outi Salo-Ahen (outi.salo-ahen(at)abo.fi)

Prof. Antti Poso’s main research interest has been computer-aided drug design and early hit/lead identification and optimization. He did his post-doctoral research as a Humboldt-fellow in Düsseldorf with Prof. H.-D. Höltje (1997-1998) and after returning to Finland he started his own molecular modeling group. One of his first major research topics was to identify and optimize sirtuin inhibitors, especially against Sirt2. His group has also contributed substantially to the design of new compounds targeting different proteins of the endogenous cannabinoid system, such as CB1 and CB2 receptors as well as MAGL and FAAH enzymes. In recent years, his interest has shifted mainly to anti-cancer and anti-infective drug design, although he is also active in projects aiming to find new therapies to age-related macular degeneration. Besides his position at the University of Eastern Finland, he has also worked at FIMM (Helsinki) with Prof. Kallioniemi and since 2012 as a Guest Professor at the University of Tübingen (Germany) with professors Zender and Laufer.

About the seminar topic:

The seminar talk will discuss three separate projects in anti-cancer drug discovery. The introduction will give a brief overview of the methods used in Kuopio and Tübingen. The first case study is about a ribosomal drug targeting project and how early computational work is mandatory for a successful druggable target identification. The other two projects (targeting a kinase and DNA replication proteins) are both currently in the late lead-optimization phase.

 

“From drug design to target selection: developing new anti-cancer and CNS-targeting compounds”

Prof. Antti Poso, University of Eastern Finland, School of Pharmacy; Distinguished Guest Professor at the University of Tübingen in Germany

Host: Outi Salo-Ahen (outi.salo-ahen(at)abo.fi)

Prof. Antti Poso’s main research interest has been computer-aided drug design and early hit/lead identification and optimization. He did his post-doctoral research as a Humboldt-fellow in Düsseldorf with Prof. H.-D. Höltje (1997-1998) and after returning to Finland he started his own molecular modeling group. One of his first major research topics was to identify and optimize sirtuin inhibitors, especially against Sirt2. His group has also contributed substantially to the design of new compounds targeting different proteins of the endogenous cannabinoid system, such as CB1 and CB2 receptors as well as MAGL and FAAH enzymes. In recent years, his interest has shifted mainly to anti-cancer and anti-infective drug design, although he is also active in projects aiming to find new therapies to age-related macular degeneration. Besides his position at the University of Eastern Finland, he has also worked at FIMM (Helsinki) with Prof. Kallioniemi and since 2012 as a Guest Professor at the University of Tübingen (Germany) with professors Zender and Laufer.

About the seminar topic:

The seminar talk will discuss three separate projects in anti-cancer drug discovery. The introduction will give a brief overview of the methods used in Kuopio and Tübingen. The first case study is about a ribosomal drug targeting project and how early computational work is mandatory for a successful druggable target identification. The other two projects (targeting a kinase and DNA replication proteins) are both currently in the late lead-optimization phase.

 

Wednesday, October 4, 2017 at 12:00
Dentalia Auditorium (Arje Scheinin), 2nd floor, Lemminkäisenkatu 2, Turku

Prof. W. Brent Derry, The Hospital for Sick Children and Department of Molecular Genetics, University of Toronto

Host: Annika Meinander (ÅAU Cell Biology and Receptor Programme)

The broad goal of Derry’s research is to understand how genes that are mutated in various diseases function in vivo. He uses the powerful genetics and functional genomics tools of the model organism Caenorhabditis elegans to understand how tumour suppressors and oncogenes control cell survival, genome stability and organism development. He is particularly interested in how cells communicate with one another to sculpt organs and make life or death decisions when challenged with stresses, such as chemotherapy and radiation. Derry also has a robust research program that is focused on understanding the mechanistic basis of the human neurovascular disease cerebral cavernous malformations (CCM). He is collaborating with an international team of scientists and clinicians to discover drugs that can be used to prevent the onset of CCM in humans.

Selected publications:
Pal, S., Lant, B., Yu, B., Tian, R., Tong, J., Krieger, J.R., Moran, M.F., Gingras, A.C., & Derry, W. B. CCM-3 Promotes C. elegans germline development by regulating vesicle trafficking cytokinesis and polarity. (2017) Current Biology. 27(6): 868-876.

Eroglu, M. & Derry, W.B. (2016) Your neighbours matter – non-autonomous control of apoptosis in development and disease. Cell Death and Differentiation. 23(7): 1110-1118.

Mateo, A.R, Kessler, Z., Jolliffe, A.K., McGovern, O., Yu, B., Nicolucci, A., Yanowitz, J.L. & Derry, W.B. (2016) The p53-like protein CEP-1 is required for meiotic fidelity in C. elegans. Current Biology. 26(9): 1148-1158.

Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC, Derry WB. (2015) CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Nature Communications. 6: 6449.

Baruah, A., Chang, H., Hall, M., Yuan, J., Gordon, S., Johnson, E., Shtessel, L.L., Yee, C., Hekimi, S., Derry, W.B., & Lee, S.S. (2014). CEP1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants. PLoS Genetics. 10(2): e1004097.

Perrin, A.J., Gunda, M., Yu, B., Yen, K., Ito, S., Forster, S., Young, J., Tissenbaum, H.A. & Derry, W.B. (2013). Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death and Differentiation. 20(1): 97-107.

Ross, A.J., Li, M., Yu, B., Gao, M.X. & Derry, W.B. (2011). The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Cell Death and Differentiation. 18(7): 1140-1149.

Ito, S., Greiss, S., Gartner, A. & Derry, W.B. (2010). Cell-nonautonomous regulation of C. elegans germ cell death by kri-1. Current Biology. 20(4): 333-338.

Gao, X. Liao, E., Yu, B., Wang, Y., Zhen, M. & Derry, W.B. (2008). The SCFFSN-1 ubiquitin ligase controls CEP-1/p53-dependent apoptosis in Caenorhabditis elegans. Cell Death and Differentiation. 15(6): 1054-1062.

Quevedo, C., Kaplan, D.R. & Derry, W.B. (2007). AKT-1 regulates DNA-damage induced germline apoptosis in C. elegans. Current Biology. 17(3): 286-292.

“Regulation of oncogenic Ras by alternative polyadenylation and microRNAs”

Prof. W. Brent Derry, The Hospital for Sick Children and Department of Molecular Genetics, University of Toronto

Host: Annika Meinander (ÅAU Cell Biology and Receptor Programme)

The broad goal of Derry’s research is to understand how genes that are mutated in various diseases function in vivo. He uses the powerful genetics and functional genomics tools of the model organism Caenorhabditis elegans to understand how tumour suppressors and oncogenes control cell survival, genome stability and organism development. He is particularly interested in how cells communicate with one another to sculpt organs and make life or death decisions when challenged with stresses, such as chemotherapy and radiation. Derry also has a robust research program that is focused on understanding the mechanistic basis of the human neurovascular disease cerebral cavernous malformations (CCM). He is collaborating with an international team of scientists and clinicians to discover drugs that can be used to prevent the onset of CCM in humans.

Selected publications:
Pal, S., Lant, B., Yu, B., Tian, R., Tong, J., Krieger, J.R., Moran, M.F., Gingras, A.C., & Derry, W. B. CCM-3 Promotes C. elegans germline development by regulating vesicle trafficking cytokinesis and polarity. (2017) Current Biology. 27(6): 868-876.

Eroglu, M. & Derry, W.B. (2016) Your neighbours matter – non-autonomous control of apoptosis in development and disease. Cell Death and Differentiation. 23(7): 1110-1118.

Mateo, A.R, Kessler, Z., Jolliffe, A.K., McGovern, O., Yu, B., Nicolucci, A., Yanowitz, J.L. & Derry, W.B. (2016) The p53-like protein CEP-1 is required for meiotic fidelity in C. elegans. Current Biology. 26(9): 1148-1158.

Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC, Derry WB. (2015) CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Nature Communications. 6: 6449.

Baruah, A., Chang, H., Hall, M., Yuan, J., Gordon, S., Johnson, E., Shtessel, L.L., Yee, C., Hekimi, S., Derry, W.B., & Lee, S.S. (2014). CEP1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants. PLoS Genetics. 10(2): e1004097.

Perrin, A.J., Gunda, M., Yu, B., Yen, K., Ito, S., Forster, S., Young, J., Tissenbaum, H.A. & Derry, W.B. (2013). Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death and Differentiation. 20(1): 97-107.

Ross, A.J., Li, M., Yu, B., Gao, M.X. & Derry, W.B. (2011). The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Cell Death and Differentiation. 18(7): 1140-1149.

Ito, S., Greiss, S., Gartner, A. & Derry, W.B. (2010). Cell-nonautonomous regulation of C. elegans germ cell death by kri-1. Current Biology. 20(4): 333-338.

Gao, X. Liao, E., Yu, B., Wang, Y., Zhen, M. & Derry, W.B. (2008). The SCFFSN-1 ubiquitin ligase controls CEP-1/p53-dependent apoptosis in Caenorhabditis elegans. Cell Death and Differentiation. 15(6): 1054-1062.

Quevedo, C., Kaplan, D.R. & Derry, W.B. (2007). AKT-1 regulates DNA-damage induced germline apoptosis in C. elegans. Current Biology. 17(3): 286-292.

Wednesday, October 4, 2017 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Akira Takeda, University of Turku

Host: Raine Toivonen

“Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression”

Akira Takeda, University of Turku

Host: Raine Toivonen

#September

Wednesday, September 27, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Simo Nikkari, Center for Military Medicine

Host: Alex-Mikael Barkoff

 

“From GHSA assessments to the JEE Alliance”

Simo Nikkari, Center for Military Medicine

Host: Alex-Mikael Barkoff

 

Tuesday, September 26, 2017 at 14:15
T32, Dentalia 2nd floor, Lemminkäisenkatu 2, Turku

Paolo Pesaresi and Carlotta Peracchio, Università degli studi di Milano

“GUN1, a Jack-Of-All-Trades in Chloroplast Protein Homeostasis and Signaling”

Paolo Pesaresi and Carlotta Peracchio, Università degli studi di Milano

Monday, September 25, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Dr. Marc Therrien, Université de Montréal, Montreal, Quebec, Canada

“Structural characterization and pharmacological targeting of dimerization-induced RAF activation”

Dr. Marc Therrien, Université de Montréal, Montreal, Quebec, Canada

Host: Daniel Abankwa

Monday, September 25, 2017 at 08:45
Mauno Conferene Center, Presidentti auditorium, BioCity, Tykistökatu 6, Turku

Turku Cancer Research Society is pleased to announce a daylong seminar on drug discovery and development entitled ‘ACADEMIC CANCER DRUG DEVELOPMENT: Challenges and successes’.

This seminar with distinguished speakers from Finland, Europe and overseas will take place on Monday September 25, 2017 in Congress Centre Mauno, Turku. For more details and registration please visit http://cancerresearch.utu.fi.

“ACADEMIC CANCER DRUG DEVELOPMENT: Challenges and successes”

Turku Cancer Research Society is pleased to announce a daylong seminar on drug discovery and development entitled ‘ACADEMIC CANCER DRUG DEVELOPMENT: Challenges and successes’.

This seminar with distinguished speakers from Finland, Europe and overseas will take place on Monday September 25, 2017 in Congress Centre Mauno, Turku. For more details and registration please visit http://cancerresearch.utu.fi.

Thursday, September 21, 2017 at 12:00
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Prof. Frank Claessens, Laboratory of Molecular Endocrinology, Leuven, Belgium

Host: Matti Poutanen

“Symmetry and allostery in the androgen receptor”

Prof. Frank Claessens, Laboratory of Molecular Endocrinology, Leuven, Belgium

Host: Matti Poutanen

Wednesday, September 20, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Subhash K. Tripathi, University of Turku

“STAT3 regulated Transcription During Early Human T helper 17 Lineage specification”

Subhash K. Tripathi, University of Turku

Wednesday, September 13, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Satu Pekkala, University of Jyväskylä

Host: Eveliina Munukka

“The bugs that live with us and metabolic disorders – from associations to mechanisms”

Satu Pekkala, University of Jyväskylä

Host: Eveliina Munukka

Thursday, September 7, 2017 at 12:00
Dentalia Auditorium (Arje Scheinin), 2nd floor, Lemminkäisenkatu 2, Turku

Dr. Eugene V Koonin, National Center for Biotechnology, Information National Library of Medicine, NIH, Bethesda, USA

“Mobile genetic elements and evolution of CRISPR-Cas systems: all the way there and back”

Dr. Eugene V Koonin, National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, USA

Host: Pere Puigbo (pepuav(at)utu.fi)

Wednesday, September 6, 2017 at 09:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Professor James Golden, University California, San Diego:
”Broad-Host-Range Genetic Tools for Cyanobacteria and Heterologous Expression of Natural Products”

Professor Susan Golden, Distinguished Professor Director, University California, San Diego:
”A Day in the Life of a Cyanobacterium: integrating temporal and environmental information”

“SmartBio Guest seminar”

Professor James Golden, University California, San Diego:
”Broad-Host-Range Genetic Tools for Cyanobacteria and Heterologous Expression of Natural Products”

Professor Susan Golden, Distinguished Professor Director, University California, San Diego:
”A Day in the Life of a Cyanobacterium: integrating temporal and environmental information”

#August

Tuesday, August 29, 2017 at 12:15
Auditorium Beta, ICT-building, Joukahaisenkatu 3-5, Turku

Professor Pirjo Nuutila, University of Turku

Chair: Jorma Toppari

Coffee will be served at 12.00
Seminar 12.15-13.00 is followed by discussion

 

“Secrets to a good grant application for the Academy of Finland”

Professor Pirjo Nuutila, University of Turku

Chair: Jorma Toppari

Coffee will be served at 12.00
Seminar 12.15-13.00 is followed by discussion

 

Wednesday, August 23, 2017 at 09:30
Dentalia, Dent 1, Lemminkäisenkatu 2, Turku

The newly formed Turku Metabolomics facility is pleased to announce a seminar to celebrate its opening.

9:30 Welcome and coffee
10:00 Matej Orešič (UTU) – Metabolomics in biomedical research: platforms, challenges, opportunities
10:10 Alex Dickens (UTU) – Biomarkers/Turku core facility
10:30 Jari Sinkkonen (UTU) – Tissue NMR for metabolomics at the NMR Instrument Centre
10:45 Mika Scheinin (UTU/Turku University Hospital) – Pharmacokinetics and verification of drug exposure
11:00 Dawei Geng (Örebro University, Sweden) – Metabolomics at Örebro University and collaboration with Turku Metabolomics facility
11:20 Linda Ahonen (Steno Diabetes Center Copenhagen, Denmark) – Lipidomics with automatized QC – case study: NIST ring trial
11:40 Kati Hanhineva (University of Eastern Finland) – Untargeted metabolomics for nutrition and food research
12:00 Reception and adjourn

“Turku Metabolomics facility opening seminar”

The newly formed Turku Metabolomics facility is pleased to announce a seminar to celebrate its opening.

9:30 Welcome and coffee
10:00 Matej Orešič (UTU) – Metabolomics in biomedical research: platforms, challenges, opportunities
10:10 Alex Dickens (UTU) – Biomarkers/Turku core facility
10:30 Jari Sinkkonen (UTU) – Tissue NMR for metabolomics at the NMR Instrument Centre
10:45 Mika Scheinin (UTU/Turku University Hospital) – Pharmacokinetics and verification of drug exposure
11:00 Dawei Geng (Örebro University, Sweden) – Metabolomics at Örebro University and collaboration with Turku Metabolomics facility
11:20 Linda Ahonen (Steno Diabetes Center Copenhagen, Denmark) – Lipidomics with automatized QC – case study: NIST ring trial
11:40 Kati Hanhineva (University of Eastern Finland) – Untargeted metabolomics for nutrition and food research
12:00 Reception and adjourn

#June

Friday, June 9, 2017 at 11:00
Turku Centre for Biotechnology, 5th floor seminar room, BioCity B-staircase, Tykistökatu 6, Turku

Dr. Lorna Young, Laboratory of Prof. Harry Higgs, Geisel School of Medicine, Dartmouth College, USA

“Interplay between filopodia, focal adhesions and stress fibers”

Friday, June 9, 2017 at 10:00
Medisiina, room C202, 2nd floor, Kiinamyllynkatu 10, Turku

Dr. Bert Dhondt, University of Ghent, Belgium

“Isolation of extracellular vesicles from biological fluids for uro-oncological biomarker studies”

Host: Jyrki Heino (jyrki.heino(at)utu.fi)

Tuesday, June 6, 2017 at 15:00
Turku Centre for Biotechnology, 5th floor seminar room, BioCity B-staircase, Tykistökatu 6, Turku

Mario Pagano, University of Padova, Italy

“Targeting the tumor suppressor PP2A: a new paradigm for paving the way to panacea?”

Host: Jukka Westermarck

Tuesday, June 6, 2017 at 12:15
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Maijaliisa Erkkola, Dep. of Food and Environmental Sciences, University of Helsinki

“Preschool as an arena for health promotion; LILLA- and DAGIS -studies”

Host: Kirsi Laitinen ( kirsi.laitinen@utu.fi )

Monday, June 5, 2017 at 10:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Michael Brenan, Research Associate, 1CellBio

“1CellBio technology for single cell analysis and the future prospective of the single cell analysis”

Host: Hongbo Zhang

 

Thursday, June 1, 2017 at 10:00
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Dr. Jan Lammerding, Nancy E. and Peter C. Meinig School of Biomedical Engineering, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, USA

“Squish and squeeze – Nuclear rupture and mechanics in cell migration and muscle disease”

Host: Pekka Taimen

#May

Wednesday, May 24, 2017 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Pirjo Merilahti University of Turku

“Receptor tropism and pathogenicity of human parechoviruses”

Host: Sisko Tauriainen

Friday, May 19, 2017 at 10:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Dr. Vinagolu K. Rajasekhar, Senior Research Scientist, Memorial Sloan Kettering Cancer Center, New York, NY

“Alternative options for clinically relevant animal modeling of human cancers”

Host: Johanna Tuomela (jomitu@utu.fi)

Thursday, May 18, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Professor David F. Stern, Department of Pathology, Yale University, New Haven, USA

“Attacking and preventing treatment-selected resistance to cancer signaling drugs”

Host: Klaus Elenius

Wednesday, May 17, 2017 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Thorsten Joeris, Lund University, Sweden

“Intestinal Antigen Presenting Cells in the regulation of mucosal CD8 T cell responses to epithelial derived antigen”

Host: Raine Toivonen

Wednesday, May 10, 2017 at 11:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Juhani Aakko University of Turku

“Mining and modelling metaproteomics data”

Host: Arno Hänninen

Friday, May 5, 2017 at 10:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Prof. Steven Pals, University of Amsterdam, The Netherlands

“Provoking homelessness as strategy to treat lymphoma”

Host: Sirpa Jalkanen

Thursday, May 4, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Professor Benjamin G. Neel, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, USA

“New tricks for old protein tyrosine phosphatases (PTPs)”

Host: Jukka Westermarck

Wednesday, May 3, 2017 at 11:15
Dentalia Auditorium (Arje Scheinin), 2nd floor, Lemminkäisenkatu 2, Turku

Teemu Smura University of Helsinki

“Zikavirus evolution”

Host: Sisko Tauriainen

Tuesday, May 2, 2017 at 12:15
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Professor Pirkko Härkönen, University of Turku

“Fibroblast growth factor receptor pathways in growth regulation and as therapeutic targets in breast and prostate cancer”

Host: Kirsi Laitinen

#April

Thursday, April 20, 2017 at 13:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Professor Brian C. Freeman, Department of Cell & Developmental Biology, University of Illinois, Urbana, Illinois, USA

“Molecular chaperones regulate the chromatin landscape. Is it time to move?”

Host: Lea Sistonen

Thursday, April 20, 2017 at 12:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Professor Hongquan Zhang, Department of Anatomy, Histology and Embryology and Laboratory of Molecular Cell Biology and Tumor

“Integrin-interacting proteins Kindlins: biology and related diseases”

Host: Jyrki Heino

Wednesday, April 12, 2017 at 14:15
Dent 2, Dentalia, Lemminkäisenkatu 2, Turku

Pirjo Merilahti, University of Turku

“Receptor tropism and pathogenicity of human parechoviruses”

Host: Sisko Tauriainen

Thursday, April 6, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Professor Dietrich Kabelitz, Department of Immunology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

“?? T-cells: An immune cell population at the cross-road of innate and adaptive immunity”

Host: Jorma Määttä

#March

Thursday, March 30, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Professor Henk Stunnenberg, Department of Molecular Biology, Radboud University, Nijmegen, The Netherlands

“Epigenomics uncovers dysregulated regulatory pathways”

Host: Riitta Lahesmaa

Thursday, March 2, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Academy professor Virpi Lummaa, University of Turku, Turku, Finland

“Births, deaths and natural selection in contemporary Finland”

Host: Jyrki Heino

#February

Friday, February 10, 2017 at 10:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Professor Carl-Henrik Heldin, Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

“Signaling via receptors for TGF? – possible targets for tumor therapy”

Host: Anna Knittle

 

#January

Thursday, January 26, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Dr. Marco Fritzsche, MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, UK

“Cytoskeletal actin dynamics underpin immunological synapse formation”

Host: Pieta Mattila

Wednesday, January 25, 2017 at 11:15
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Tero Ahola, University of Helsinki

“Discovering new antivirals agaisnt alphaviruses and other RNA viruses”

Host: Petri Susi

Thursday, January 19, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Professor Jussi Taipale, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden

“Systems biology of cancer”

Host: Jukka Westermarck

Thursday, January 12, 2017 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Professor Wouter de Laat, Hubrecht Institute, Utrecht, The Netherlands

“The use of 3C technologies to study the shape and function of the genome and enable new applications in DNA diagnostics”

Host: Riitta Lahesmaa

#December

Thursday, December 15, 2016 at 14:00
Pha3 seminar room, PharmaCity, Itäinen Pitkäkatu 4, Turku

Speaker: Dr. Julie Bouckaert, University of Lille, France

“Bacterial adhesion at the site of inflammation: a sugary liaison”

Speaker: Dr. Julie Bouckaert, University of Lille, France

Thursday, December 15, 2016 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Birgit Lane, Institute of Medical Biology and Skin Research Institute of Singapore, Nanyang Technological University, Singapore

“Lessons from rare skin diseases”

Host: Diana Toivola

Tuesday, December 13, 2016 at 14:15
Biology seminar room 215, Natura, 2nd floor, Turun yliopisto, natura, Turku, 20500

Dr. Thomas Lilley, Department of Biology, University of Turku & Bucknell University, Lewisburg, USA

“White-nose syndrome in bats”

Host: Päivi Koskinen

Tuesday, December 13, 2016 at 13:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Programme.

Registration (latest on Monday, 5 December)

“Scientific publishing – ethics, metrics and beyond”

Programme.

Registration (latest on Monday, 5 December)

Wednesday, December 7, 2016 at 16:00
Keidas, Medisiina 2nd floor, Kiinamyllynkatu 10, Turku

Programmme

Registration by 29.11. to contact-tcrs@lists.utu.fi

Please also indicate a possible special diet when registering.

“Cancer Immunology – from basic mechanisms to therapy”

Programmme

Registration by 29.11. to contact-tcrs@lists.utu.fi

Please also indicate a possible special diet when registering.

Wednesday, December 7, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Siri Tähtinen, University of Helsinki

“Oncolytic adenoviruses as enablers of efficient cancer immunotherapies”

Host: Laura Kakkola

Thursday, December 1, 2016 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Moira O’Bryan, Monash University, Clayton, Victoria, Australia

“Custom cutting – the importance of microtubule severing proteins in male fertility”

Host: Anu Sironen

#November

Wednesday, November 30, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Pieta Mattila, University of Turku

“Exploring B cell activation and the antigen processing route in B cells”

Host: Jukka Alinikula

Thursday, November 24, 2016 at 12:00
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Prof. Michael McHeyzer-Williams, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, USA

“Deconstructing B cell memory at the single cell level”

Host: Liu Chengqian

Wednesday, November 23, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Linnéa Linko, University of Turku

“Quality requirements in routine laboratory diagnostics and research”

Host: Marianne Gunell

Tuesday, November 22, 2016 at 14:15
Biology seminar room 215, Natura, 2nd floor, Turun yliopisto, natura, Turku, 20500

Adj. prof. Adolfo Rivero-Müller, Turku Centre for Biotechnology

“Gene editing technologies”

Host: Päivi Koskinen

Thursday, November 17, 2016 at 12:00
Arje Scheinin auditorium, Dentalia, 2nd floor, Lemminkäisenkatu 2, Turku

Prof. Ron van Schaik, Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands

“Clinical implementation of pharmacogenomics: do you have your DNA passport ready?”

Host: Csilla Sipeky

Wednesday, November 16, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Elina Mäntylä, University of Jyväskylä

“Viral regulation of the cell cycle”

Host: Veijo Hukkanen

Friday, November 11, 2016 at 09:30
Auditorium Alpha, ICT-building, Joukahaisenkatu 3-5, Turku

Olga Vitek, College of Science, College of Computer and Information Science, Northeastern University, Boston, USA

“MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments”

Host: Laura Elo

Thursday, November 10, 2016 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Olga Vitek, College of Science, College of Computer and Information Science, Northeastern University, Boston, USA

“From proteomics to biological insights using statistics”

Host: Laura Elo

Wednesday, November 9, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Pia Rantakari, University of Turku

“Fetal liver endothelium regulates the seeding of tissue-resident macrophages”

Host: Eveliina Munukka

Tuesday, November 8, 2016 at 14:15
Biology seminar room 215, Natura, 2nd floor, Turun yliopisto, natura, Turku, 20500

Dr. Niina Santio, Department of Biology, University of Turku

“Pim kinases in regulation of cell motility”

Host: Päivi Koskinen

Wednesday, November 2, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Teemu Kallonen, Sanger Institute, UK

“Use of whole genome sequencing to analyse Escherichia coli causing bacteremia in England”

Host: Erkki Eerola

Tuesday, November 1, 2016 at 11:00
Dentalia Auditorium (Arje Scheinin), 2nd floor, Lemminkäisenkatu 2, Turku

Anthony Chalmers, Institute of Cancer Sciences, University of Glasgow, Scotland, UK

“Understanding and targeting the abnormal DNA damage response in glioblastoma stem-like cells”

Host: Jukka Westermarck

#October

Thursday, October 27, 2016 at 15:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Prof. Jens Mittag, University of Lübeck, Lübeck, Germany

“Thyroid hormone receptor alpha 1 in the control of cardiovascular function and brown fat thermogenesis”

Host: Jukka Kero

Wednesday, October 26, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Ulvi Gürsoy, University of Turku

“Host bacteria infection”

Host: Eija Könönen

Wednesday, October 26, 2016 at 09:30
Salin Auditorium, Axelia II, Åbo Akademi, Piispankatu 8, Turku

Applications of modern mass spectrometry in life sciences

 
Programme and registration (by October 24)

“Royal Society of Chemistry – Finland Local Section, Annual Seminar in Turku”

Applications of modern mass spectrometry in life sciences

 
Programme and registration (by October 24)

Tuesday, October 25, 2016 at 14:15
Biology seminar room 215, Natura, 2nd floor, Turun yliopisto, natura, Turku, 20500

Adj. prof. Jussi Jäntti, VTT Synthetic Biology Group, Espoo

“Novel genetic tools for engineering of eukaryotic microbes”

Host: Päivi Koskinen

Wednesday, October 12, 2016 at 11:15
Dentalia, Dent 3, Lemminkäisenkatu 2, Turku

Henna-Maria Uusitupa, University of Turku

“Breastmilk and gut microbiota development”

Host: Eveliina Munukka

Thursday, October 6, 2016 at 11:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4B, Turku

Professor Anne Ridley, King´s College London, UK

“Rho GTPases: signalling in cell migration”

Host: Päivi Koskinen

Wednesday, October 5, 2016 at 14:00
Turku Centre for Biotechnology, 5th floor seminar room, BioCity B-staircase, Tykistökatu 6, Turku

Speaker: Adam Byron, Edinburgh Cancer Research UK Centre, University of Edinburgh, UK

 

“Integrative analyses of adhesion signalling networks to identify new cancer targets”

Speaker: Adam Byron, Edinburgh Cancer Research UK Centre, University of Edinburgh, UK

 

#September

Thursday, September 29, 2016 at 12:00
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6, Turku

Dr. Sophie Rousseaux, INSERM, Université Grenoble Alpes, Institut Albert Bonniot, Grenoble, France

“Cell identity loss in cancer: a source of new biomarker and therapeutic targets”

Host: Noora Kotaja